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Hyperthyroidism Symptoms Hyperthyroidism symptoms are variable but often they include: Rapid or irregular heartbeat leading to arrhythmias Losing of weight despite increased appetite Nervousness, anxiety, and easily getting irritated Tremors, usually in the hands Increased sensitivity to heat Unusual sweating leading to weight loss Changes in menstrual patterns (common hyperthyroidism symptoms in females) Fatigue and muscle weakness Difficulty sleeping leading to insomnia Females with Hyperthyroidism: Symptoms Hyperthyroidism symptoms in females can also include changes in menstrual patterns, which can cause irregular periods or changes in flow